CLARASTILL SINE eye-drops is a watery sterile solution at 0.3% of carboxymethylcellulose to be used on ocular tissues for its protective, eutrophic, moisturizing, lubricating action. Thanks to the anti-oxidative and anti-free radicals properties of its components, this medical device protects the ocular tissues (crystalline, cornea, conjunctiva) from the consequences of oxidative stress due to unfavourable environmental factors (mechanical stress due to contact lenses, solar radiation, smoke, powder, air conditioning, computer radiations) and it makes easy the recover of the natural epithelial trophism. The saline solution, base of the medical device, would remain in contact with the ocular surface only for few seconds with a transient benefit. By adding glycerine to the solution it is obtained an extraction of water from ocular tissues (moisturizing action) with the consequent formation of a thin watery film on the corneal surface which in presence of carboxymethylcellulose it is englobed in the grid of the cellulose polymer. So an hydro-gel with film and viscous-elastic properties is formed. In the medical device the concentration (0.30%) of carboxymethylcellulose has been appropriately studied to grant to the obtained hydro-gel rheologic characteristics equal to those of the lachrymal liquid and a good adhesiveness on ocular mucosa with a consequent protective, eutrophic, moisturizing and lubricating effect without causing sight blurring. We specify that N-acetylcarnosine, present in the excipients of the medical device, does not develop any particular pharmacological action but, for its natural anti-oxidative and anti-free radicals properties “it consumes” oxidazing itself and in this way it protects the ocular tissues (crystalline, cornea, conjunctiva) from the assaults of cellular lipidic peroxidases.
CLARASTILL SINE is characterized by the following chemical-physical properties: it is perfectly transparent, mixable with water (and with lachrymal liquid) in all proportions, it does not form insoluble precipitates with the metal salts or with organic remnants eventually present in the lachrymal liquid; it has a pH and an osmolarity values perfectly compatible with the ocular tissue and with the lachrymal liquid and for this reason, it has a high tolerability. The product does not containe salts of quaternary ammonium (benzalkonium, cetrimide), for this reason it can be used also by wearers of rigid and soft contact lenses.
